A Cure for Aging
by Michael Dickey
A few days ago I visited a local hospital. What a disgusting, sad place. The hospital had people everywhere dying, families fooling themselves that all will be fine, then insisting it was for the best when all is not. Lives unique in all of time and the entire universe withering away. We grow old, and weak, and deteriorate. The machines that house our consciousness fail system-by-system, collapsing, imploding and erupting. We spend our lives acquiring and embracing knowledge, knowledge of life, love, and happiness... Then the neurons support system fails, cells decay, and all that information is lost, forever. Our favorite songs, our soul mates, secret passions and high hopes, our stories told and heard, adventures embarked upon, and battles fought, for better or worse. The things that define our very essence, gone forever. Why bother collecting the and processing all that information, when it all eventually lost anyway.
What's the point!?
It is better to have lived and died than to have never lived at all. But better by far to live and never die.
I wonder what my father was like when young? I wonder what he would be doing if granted a young healthy body to house his consciousness right now. Might he pursue that other career he wanted? Play baseball some more? My mother, might she fulfill her dream of teaching? My grandparents I barely or never knew. What were their hobbies and interests? What would they be interested in if young and healthy today? Their parents, who grew up in worldwide wretched poverty? Their parents who fled oppressive poor homelands for the hope of a better life? I would like to thank them for taking such an incredible risk. I wonder what those brave great ancestors of mine where like.
A cell is damaged, its DNA bombarded by ionizing radiation, the genes ripped apart. Its mitochondria, its power plant, machine gunned by free radicals, ripped apart here and there. The cell dies, and damage is done to the systems it is a part of. The system recovers when the cell and its functionality are replaced.
When a cell's genetic structure is damaged, it is either rendered non-functional, taking its purpose with it and away from the system it supports, or it remains functional. If remaining functional, it is either unchanged or changed. If changed, it's usually for the worse, changing the function of the cell, producing the wrong enzyme, or producing nothing at all. If it survives and is changed, it eventually copies itself, copying the change along with it. Now two cells in a system are incorrect, their DNA and thus functioning different from what is necessary to maintain the system they are a part of.
Other cells in that system, over time, must undergo changes as well, and more and more cells in a system fail at their intended duty, the original genetic instructions swept spec by spec under the carpet of entropy, forever lost. These cells copy, and build further errors. Some cells have particular parts of their DNA damaged; a part that enables those cells to copy themselves. This damage prevents the cells from copying, leaving a gap in the required cells for the operation of a body, and leading eventually to fewer cells present to serve a function and support a system. Each cell has a finite potential for copying, and the more that are unable to copy, the fewer cells the body of the future has, and the easier other cell damage and failure can catastrophically effect a system and subsequently the entire body.
Some cells are still able to copy cells copy themselves along with their errors, and more and more working cells end up developing errors through radiation, accidents, or interference. The effect, over time, is that more and more cells operate more and more improperly, while more and more of the original DNA sequence is lost to time. Sometimes a cell critical to a system changes, and a catastrophic failure ensues, collapsing the functionality of one of the many dependant systems in the body. Sometimes a system requires a certain percentage of its cells to function properly, and when more than that percentage operate improperly in the pertinent manner, the entire system, or organ, or process can fail nearly instantly.
Imagine a pillar holding a weight. The pillar is made of millions of small objects, like balloons. Over time, random damage pops a balloon here or there, or decreases the strength of a balloon. The random damage is representative of the damage cells undergo, with the balloon representative of the cells. As more and more of the balloons fail and pop, the balloons find it more difficult to hold up the weight. Sometimes when one balloon pops, it pops a vertical line of 10 balloons adjacent to it. Sometimes one balloon pops and causes five other random ones to pop. Eventually, one too many balloons pop, and the weight collapses, even though there may be plenty of good balloons left. The weight may come crashing to the ground in a catastrophic failure, or slowly sink as more systems fail. That weight is life; the balloons are the cells and their processes supporting life. Eventually, it fails, and all comes crashing down. Sometimes the fall is slow, but when it goes below a certain point, when it touches the ground, the systems and function in the body are not able to sustain the process needed for life, and the entity dies.
How to keep the weight up? How to keep life aloft? Keep adding new balloons...
Me: currently I am writing my cure for aging theory out though
Friend: Really? You'll have to send me a sample, preferably in English..
Me: sure, still working on it, but basically...
Me: Life is supported by a system or group of processes
Me: e.g. breathing, eating, sleeping, etc.
Friend: lol, still with you..
Me: those systems and process are supported by the function of the cells that make them up
Me: the functioning of a cell is determined by its internal structure, primarily its DNA
Friend: mmm hmm..
Me: over time, damage occurs to the cells, sometimes to the dna, and sometimes to the other various components in the cells
Me: if they are damaged, they change functionally, or die all together
Friend: all right..
Me: if they live, they eventually copy, copying their change in functionality with them
Me: that changed function supports some system or another, and the more cells that support that system that change, the more likely that system is to fail
Me: eventually, if one waits long enough, all cells are damaged and function improperly
Me: if enough are damaged, the systems and process that support life are damaged, and the body is unable to sustain itself
Me: aging is, at least a significant part of it is, the cumulative buildup of all those functional deficiencies
Me: so, to combat aging, one must fight the failures of the proper functioning of cells
Me: the proper functioning of a cell is determined by its proper DNA (your genome) each cell though, eventually, gets a different genome, over time
Me: essentially, take a cell with the correct genome and store it away from radiation (or sequence it)
Me: clone it into a clump of stem cells
Me: stem cells are produced in your bone marrow and enter the blood stream, but the stem cell manufacturing process are also governed by cells, and can be damaged
Me: so, give yourself periodic injections of stem cells which always contain your original DNA, the body sends them where they need to go, and they continue to allow the body to function properly
Me: that's it
Me: stem cell injections, that's my theory and I'm sticking to it
Friend: lol, well, I'm in neither a medical position to debate it or a political position (yet) to approve it, so I'll say it at least seems reasonable enough to me in the form you presented.
Me: indeed... well, it could be entirely off base. I'm not sure if the correctly functioning stem cells will actually get where they need to go, say to the end of your finger or something like that
Me: perhaps localized injections in help with that. Requires more research
Friend: lol, doesn't everything though?
Me: indeed, but unfortunately it cuts into everyone's TV watching time
So there you have it, to combat aging, give yourself regular injections of your own cloned stem cells. Keep a primary batch of stem cells away from mutative influences. This is, in principle, impossible in a perfect sense, but a significant advantage would be to sequence your own genome, and clone stem cells that match that genome. Additionally, the cloned stem cells could be made to contain the DNA of traits you prefer to acquire, to a limited extent.
Getting regular, and possible localized injections of your own cloned stem cells is like getting organ transplants at the microscopic level over time. There is no rejection, and the system that the cells of that organ support remain operationally and intact. The cumulative entopic buildup of errors is combated with the genome being stored and referenced externally. The bodies own bone marrow gets subjected to the same errors and barrage of carcinogens, radiation, and toxins that the rest of the body does, and this is the source of the cells that replenish the body. This is why leukemia, a cancer of the bone marrow, is such a terrible and deadly disease, and why it can be cured with a bone marrow transplant. Replacing functionally deficient bone marrow with functional marrow.
Do you have a failing liver? Clone some of your own stem cells, and inject them right into the liver, keeping the number of functional cells above the minimum requirement for the system they support to operate correctly, and you experience none of the ravages of aging on systems.
Is your pancrease not able to process insulin? Inject some of your own stem cells, which have had the appriate genetic modifications, into your pancrease.
What about Telomere theory of aging?
The telomere gene is one that resides at the end of your DNA strands, they serve as the buffer at the end of the line. When the DNA copying mechanism copies the DNA of a cell, it stops before it hits the last telomere sequence, copying all the previous ones. With each copy, there is one less telomere sequence, eventlually, there are no more, and the copying process stops. The researcher who discovered this found that the typical cell can copy itself around 50 times before it reaches what has since become known as the Hayflick Limit, after said researcher. At an average of around 1.5 years to copy, your average cellular life span seems to hit right around that 75 year mark. Some Cancer cells reproduce all of their telomere sequences, and are effectively immortal. Most cancer cells, however, reproduce as quickly as possible, consuming all available resources, growing into undifferentitated tumors. Much promising research suggests curing the telomere sequence copying problem in cells, removing the genetically determined finite life span of cells, is on the horizon, and often this is touted as a cure for aging. Curing the telomere problem, however, will do nothing for the cumulate ravages of existence that build up in cells from radiation, stress, environment, etc. Entropy still destroys us as the repair mechanisms themselves get damaged.
Keeping a referenced repair mechanism at hand is the key, in the short term a bank of your own cloned stem cells, hopefully a genetic combination of a large sample, so your original and 'pure' genetic code can be used as reference. Inexpensive genome sequencing and genome manipulation will be required for this step, but in the short term to combat age related deterioation a batch of your own stem cells will help. Long term your sequence can be stored as just that, a sequence in a computer, with no need to worry about protecting a batch of cells from radiation and ravages from the environment.
What diseases can Stem Cell injections combat?
It is possible, indeed quite probably that stem cell injections can and will be used to treat and cure nearly every disease. But the most promising advances recently have been in the Parkinsons disease, Heart disease, and diabetes.
Parkinson's disease is a very common neuro-degenerative disorder that affects more than 2% of the population over 65 years of age. PD is caused by a progressive degeneration and loss of dopamine (DA)-producing neurons, which leads to tremor, rigidity, and hypokinesia (abnormally decreased mobility) A loss of dopamine producing neurons? Well, what happened to these neurons that made them no longer able to produce dopamine? No doubt it was a change to their internal structuring, most likely their DNA. Implanting properly functioning neurons which generate dopamine would cure Parkinsons, or, more simply, implanting a genetically pure stem cell which will turn into a correctly functioning dopamine producing neuron will cure parkinsons. Indeed, Parkinsons is thought to be one of the first diseases that will be cured by Stem Cell technology.
Type I diabetes come from an inability of cells within the pancrease to produce Insulin, requiring victims to have regular insulin shots. injecting a few correctly functioning cells resolves the problem.
Heart Disease studies have shown tears and physical damage to a heart can be repaired (not surprisingly to me) by localized stem cell injections.
Most, if not all, genetic diseases can be cured with Stem Cell injections!
In some cases, the injected cells have come from donors, bringing up the problem
of rejection. A better scenerio would have been to use the patients own stem
cells. In the case of a cumulative aging-related disorder, this would work fine,
in the case of a genetic disorder however, modification would be required to
correct the functioning problems of the cells. Eventually all the cells of the
system or organ will be replaced by correctly functioning ones as the genetically
incorrect ones the patient inherited die off. Thus most, if not all, genetic
diseases can be cured with such injections.
In fact, since transplants of any kind are in their simplest form the replacing of a improperly functioning organ with a properly functioning one, then any kind of transplant may be replaced eventually by simple localized stem cell injections. No organ shortages, no rejection problems.
What Injuries can stem cell injections combat?
Physicall injuries, such as burns, are all ready treated by localized stem cell applications. It seems likely that, cuts, bruises, and broken bones can all be helped by stem cell injections, as this is a significant component of how they are healed in the first place. It is feasible that even scar tissue can be removed with Stem Cell treatments.
What can stem cell injections not do?
It seems unlikely that Stem Cells will be able to replace significant inherited physical traits, like overbites, scoliosis, or someone being to tall or short for their own tasts. But who knows? With your teeth, they are generally created young, and stay that way. Only systems that are continually recreated can be helped by stem cell injections.
It sounds easy, have parkinsons? Have your doctor give you an injection. Arthritis? An injection into the offending knee. Diabetes? An injection into the pancrease. If bone marrow stem cells are indeed the precursors throughout the body, then it may be possible the injections of stem cells into the blood stream use the bodies own systems to correct any problems anywhere in the body automatically! But maybe not, supposing that localized injections are required, what are the possible problems with that? Have any cases shown injected stem cells doing bad things?
Side effects of stem cell injections?
Few side effects are so far known of localized stem cell injections, but the research is still young. Of note, in one case stem cells were injected into a liver, and they fused with existing liver cells, instead of forming into their own liver cells. The liver cells were still coaxed into operating properly however.
In short, localized stem cell injections may actually be a cure for the cumulative system damage that occurs and is a primary cause of aging and all age related disease.
Related original articles - Aging related diseases are not the only threats to our health, obesity, cancer, heart disease, and bodily injury rank high up there. See my related articles on "A Cure of Obesity" "A Cure for Cancer" "A Cure for Heart Disease" and "The Encounter Suit, a Cure for Injury" Afraid of the global ravages of immortality, see "The Immortal Future" (all coming soon!)
Authors Disclaimer - I make no claims that this article is an original discovery in time, or claims that I alone deserve credit for this discovery, this is merely a retelling of my personal road to discovery, and it is, at least, an original discovery to me.
Back to www.Matus1976.com
Further Reading -
Google search on "Stem Cell Injections" - http://www.google.com/search?hl=en&lr=&ie=ISO-8859-1&safe=off&q=stem+cell+injections
Stem Cell Primer - http://www.nih.gov/news/stemcell/primer.htm
Cloned Stem Cells cure Parkinsons in rat model - http://www.sciencedaily.com/releases/2002/05/020510074808.htm
"Paul Carvey, PhD, chairman of pharmacology at Rush, used his team's discovery to clone several generations of stem cells that, when grafted into the brains of rats with a Parkinson's like disease, developed into healthy dopamine neurons. This effectively cured the animals' severe Parkinsonian symptoms"
"Many people confuse all types of stem cells with embryonic stem cells, which are taken from the earliest stages of an embryo, generally at 32 cells or less. Such cells have the potential to turn into dopamine neurons when implanted in the brains of humans with Parkinson's disease. Carvey's group did not want to work with this type cell, however, not because of the political difficulties but because it is only at the beginning of the lineage restriction pathway."
Stem Cells reduce brain damage - http://www.news.harvard.edu/gazette/2002/11.21/01-stem.html
"Snyder was surprised to see that stem cells not only replaced missing brain tissue, but provided protection for cells disabled by age and diseases like Parkinson's and Alzheimer's. "It's not unreasonable to think that in humans the early implantation of stem cells - because of partnerships they form with host cells - might forestall or even pre-empt degenerative diseases such as Parkinson's and Alzheimer's," Snyder says."
"These demonstrations of neural stem cells' capacity to repair and protect a brain leads Snyder to speculate that other types of stem cells could perform the same functions in other organs, such as the heart, muscles, lungs, and liver. "Stem cells, in the broadest sense, are responsible for putting organs together in the womb," he notes. "They are a normal part of development, so maybe we can find ways of fooling the injured or dysfunctional body into believing that development is still going on.""
Transplant can cure diabetes - http://www.charlotte.com/mld/charlotte/living/columnists/karen_garloch/4646206.htm
Jody DeMarco came to Charlotte recently to give hope to those with juvenile diabetes. The 46-year-old Philadelphian is one of 140 people in the world whose diabetes has been cured by a transplant of islet cells Islet cells -- short for islets of Langerhans -- are clusters of cells in the pancreas. They contain beta cells, which secrete insulin needed to regulate the metabolism of sugar. A malfunction of that process causes diabetes. Two years ago, Canadian researchers reported the first successful human transplants of islet cells from donor cadavers. Today, eight centers in the United States, Canada and Europe perform such transplants with funding from the JDRF"
[Authors comment - Again, here we see properly functioning cells, this time from a donor, injected into a organ with cells that do not function properly, and the system they support, in this case the generation of insulin, remains functional. These donor cells were taken from cadavers. A better scenerio would be to use the patients own stem cells. Indeed the article later notes.. - MFD]
"Therapeutic cloning of a person's own stem cells could produce sufficient islet cells in the future, Gores said. By then, researchers may have figured out how to stop the autoimmune problem that destroyed the person's islet cells in the first place"
The Harvard Biotech Club, Emerging Technologies - Stem Cells http://www.thebiotechclub.org/industry/emerging/stem_cells.php
"Heart. Several groups have been working on animal models in which pluripotent stem cells are grafted into damaged hearts. The stem cells were shown to incorporate into the heart and form gap junctions and beat with the surrounding cells"
Turning Stem cells into Liver cells - http://www.healthandage.org/Home/gm=20!gid1=3658
"The animals were injected with adult stem cells and the researchers found that these could, indeed, become liver cells. But what was occurring was cell fusion rather than cell transformation. A stem cell fused with a liver cell, to make a new liver cell with extra numbers of chromosomes."
[Interestingly, these researches injected adult stem cells into a liver which was not functioning properly, the stem cells took root and made the liver function properly, however, they fused with existing cells instead of forming into proper liver cells. - MFD]
Stem Cells and Retinal Restoration - http://www.focusnewsletter.org/stemcell.htm
"Patients with retinal problems will need stem cell transplantation and/or activation of their own cells with growth factors. This developing science does overlap with that of gene therapy, which seeks to correct errors in DNA so that harmful mutations aren't expressed."
The Stem Cell Research Foundations FAQ on Stem Cells - http://www.stemcellresearchfoundation.org/About/FAQ.htm
"Cell therapy can be defined as a group of new techniques, or technologies, that rely on replacing diseased or dysfunctional cells with healthy, functioning ones. These new techniques are being applied to a wide range of human diseases, including many types of cancer, neurological diseases such as Parkinson's and Lou Gehrig's Disease, spinal cord injuries, and diabetes. Replacing dead cells in the retina with new ones may someday cure even presently incurable eye diseases such as glaucoma and macular degeneration"